diff --git a/crates/ty_python_semantic/resources/mdtest/slots.md b/crates/ty_python_semantic/resources/mdtest/slots.md
new file mode 100644
index 0000000000..f3198d10f8
--- /dev/null
+++ b/crates/ty_python_semantic/resources/mdtest/slots.md
@@ -0,0 +1,62 @@
+# `__slots__`
+
+## Basic slot access
+
+```py
+class A:
+    __slots__ = ("foo", "bar")
+
+    def __init__(self, foo: int, bar: str):
+        self.foo = foo
+        self.bar = bar
+
+a = A(1, "zip")
+a.foo = 2
+a.bar = "woo"
+a.baz = 3  # error: [unresolved-attribute]
+```
+
+## Accessing undefined attributes
+
+```py
+class A:
+    __slots__ = ("x",)
+
+a = A()
+a.y = 1  # error: [unresolved-attribute]
+```
+
+## Empty slots
+
+```py
+class A:
+    __slots__ = ()
+
+a = A()
+a.x = 1  # error: [unresolved-attribute]
+```
+
+## Single character string
+
+```py
+class A:
+    __slots__ = "x"
+
+a = A()
+a.x = 1  # error: [possibly-missing-attribute]
+a.y = 2  # error: [unresolved-attribute]
+```
+
+## Multi-character string
+
+```py
+class A:
+    __slots__ = "xyz"
+
+a = A()
+a.x = 1  # error: [possibly-missing-attribute]
+a.y = 2  # error: [possibly-missing-attribute]
+a.z = 3  # error: [possibly-missing-attribute]
+a.xyz = 4  # error: [unresolved-attribute]
+a.q = 5  # error: [unresolved-attribute]
+```
diff --git a/crates/ty_python_semantic/src/types/class.rs b/crates/ty_python_semantic/src/types/class.rs
index 61ee82e030..8fee89c060 100644
--- a/crates/ty_python_semantic/src/types/class.rs
+++ b/crates/ty_python_semantic/src/types/class.rs
@@ -3773,14 +3773,17 @@ impl<'db> ClassLiteral<'db> {
                     // The attribute is not *declared* in the class body. It could still be declared/bound
                     // in a method.
 
-                    Self::implicit_attribute(db, body_scope, name, MethodDecorator::None)
+                    let result =
+                        Self::implicit_attribute(db, body_scope, name, MethodDecorator::None);
+                    self.apply_slots_constraints(db, name, result.inner)
                 }
             }
         } else {
             // This attribute is neither declared nor bound in the class body.
             // It could still be implicitly defined in a method.
 
-            Self::implicit_attribute(db, body_scope, name, MethodDecorator::None)
+            let result = Self::implicit_attribute(db, body_scope, name, MethodDecorator::None);
+            self.apply_slots_constraints(db, name, result.inner)
         }
     }
 
@@ -5957,6 +5960,92 @@ impl SlotsKind {
     }
 }
 
+/// Helper functions for __slots__ support
+impl<'db> ClassLiteral<'db> {
+    /// Extract the names of attributes defined in __slots__ as a set of strings.
+    /// Returns None if __slots__ is not defined, empty, or dynamic.
+    pub(super) fn slots_members(self, db: &'db dyn Db) -> Option<FxHashSet<String>> {
+        let Place::Defined(slots_ty, _, definedness) = self
+            .own_class_member(db, self.generic_context(db), None, "__slots__")
+            .inner
+            .place
+        else {
+            return None;
+        };
+
+        if matches!(definedness, Definedness::PossiblyUndefined) {
+            return None;
+        }
+
+        match slots_ty {
+            // __slots__ = ("a", "b")
+            Type::NominalInstance(nominal) => {
+                if let Some(tuple_spec) = nominal.tuple_spec(db) {
+                    let mut slots = FxHashSet::default();
+                    for element in tuple_spec.all_elements() {
+                        if let Type::StringLiteral(string_literal) = element {
+                            slots.insert(string_literal.value(db).to_string());
+                        } else {
+                            // Non-string element, consider it dynamic
+                            return None;
+                        }
+                    }
+                    Some(slots)
+                } else {
+                    None
+                }
+            }
+
+            // __slots__ = "abc"  # Expands to slots "a", "b", "c"
+            Type::StringLiteral(string_literal) => {
+                let mut slots = FxHashSet::default();
+                let slot_value = string_literal.value(db);
+
+                // Python treats a bare string as a sequence of slot names (one per character)
+                for ch in slot_value.chars() {
+                    slots.insert(ch.to_string());
+                }
+                Some(slots)
+            }
+
+            _ => None,
+        }
+    }
+
+    /// Apply __slots__ constraints to attribute access.
+    fn apply_slots_constraints(
+        self,
+        db: &'db dyn Db,
+        name: &str,
+        result: PlaceAndQualifiers<'db>,
+    ) -> Member<'db> {
+        // TODO: This function will be extended to support:
+        // - Inheritance: Check slots across the MRO chain
+        // - `__dict__` special case: Allow dynamic attributes when `__dict__` is in slots
+
+        if let Some(slots) = self.slots_members(db) {
+            if slots.contains(name) {
+                // Attribute is in __slots__, so it's allowed even if not found elsewhere
+                if result.place.is_undefined() {
+                    // Return as possibly unbound since it's declared but not necessarily initialized
+                    return Member {
+                        inner: Place::Defined(
+                            Type::unknown(),
+                            TypeOrigin::Inferred,
+                            Definedness::PossiblyUndefined,
+                        )
+                        .into(),
+                    };
+                }
+                return Member { inner: result };
+            }
+            // Attribute is not in __slots__
+            return Member::unbound();
+        }
+        Member { inner: result }
+    }
+}
+
 #[cfg(test)]
 mod tests {
     use super::*;