diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_simplify/SIM115.py b/crates/ruff_linter/resources/test/fixtures/flake8_simplify/SIM115.py
index 46e01a4f84..88af984ce4 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_simplify/SIM115.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_simplify/SIM115.py
@@ -264,3 +264,22 @@ def func(filepath, encoding):
 # OK
 def func(filepath, encoding):
     return f(open(filepath, mode="rt", encoding=encoding))
+
+
+from unittest import IsolatedAsyncioTestCase, TestCase
+
+# OK
+class ExampleClassTests(TestCase):
+    @classmethod
+    def setUpClass(cls):
+        cls.enterClassContext(open("filename"))
+
+# OK
+class ExampleAsyncTests(IsolatedAsyncioTestCase):
+    async def test_something(self):
+        await self.enterAsyncContext(open("filename"))
+
+# OK
+class ExampleTests(TestCase):
+    def setUp(self):
+        self.enterContext(open("filename"))
\ No newline at end of file
diff --git a/crates/ruff_linter/src/rules/flake8_simplify/rules/open_file_with_context_handler.rs b/crates/ruff_linter/src/rules/flake8_simplify/rules/open_file_with_context_handler.rs
index e17aeb59de..fc36a1acfc 100644
--- a/crates/ruff_linter/src/rules/flake8_simplify/rules/open_file_with_context_handler.rs
+++ b/crates/ruff_linter/src/rules/flake8_simplify/rules/open_file_with_context_handler.rs
@@ -114,6 +114,28 @@ fn match_exit_stack(semantic: &SemanticModel) -> bool {
     false
 }
 
+/// Return `true` if the current expression is nested in a call to one of the
+/// unittest context manager methods: `cls.enterClassContext()`,
+/// `self.enterContext()`, or `self.enterAsyncContext()`.
+fn match_unittest_context_methods(semantic: &SemanticModel) -> bool {
+    let Some(expr) = semantic.current_expression_parent() else {
+        return false;
+    };
+    let Expr::Call(ast::ExprCall { func, .. }) = expr else {
+        return false;
+    };
+    let Expr::Attribute(ast::ExprAttribute { attr, value, .. }) = func.as_ref() else {
+        return false;
+    };
+    let Expr::Name(ast::ExprName { id, .. }) = value.as_ref() else {
+        return false;
+    };
+    matches!(
+        (id.as_str(), attr.as_str()),
+        ("cls", "enterClassContext") | ("self", "enterContext" | "enterAsyncContext")
+    )
+}
+
 /// Return `true` if the expression is a call to `open()`,
 /// or a call to some other standard-library function that opens a file.
 fn is_open_call(semantic: &SemanticModel, call: &ast::ExprCall) -> bool {
@@ -229,6 +251,11 @@ pub(crate) fn open_file_with_context_handler(checker: &Checker, call: &ast::Expr
         return;
     }
 
+    // Ex) `self.enterContext(open("foo.txt"))`
+    if match_unittest_context_methods(semantic) {
+        return;
+    }
+
     // Ex) `def __enter__(self): ...`
     if let ScopeKind::Function(ast::StmtFunctionDef { name, .. }) =
         &checker.semantic().current_scope().kind