diff --git a/crates/red_knot_python_semantic/resources/mdtest/annotations/tuple.md b/crates/red_knot_python_semantic/resources/mdtest/annotations/tuple.md
new file mode 100644
index 0000000000..1903c01f82
--- /dev/null
+++ b/crates/red_knot_python_semantic/resources/mdtest/annotations/tuple.md
@@ -0,0 +1,15 @@
+# Tuple
+
+## `Never`
+
+If a tuple type contains a `Never` element, then it is eagerly simplified to `Never` which means
+that a tuple type containing `Never` is disjoint from any other tuple type.
+
+```py
+from typing_extensions import Never
+
+def _(x: tuple[Never], y: tuple[int, Never], z: tuple[Never, int]):
+    reveal_type(x)  # revealed: Never
+    reveal_type(y)  # revealed: Never
+    reveal_type(z)  # revealed: Never
+```
diff --git a/crates/red_knot_python_semantic/resources/mdtest/type_properties/is_disjoint_from.md b/crates/red_knot_python_semantic/resources/mdtest/type_properties/is_disjoint_from.md
index 3d2296807d..479bf0efb2 100644
--- a/crates/red_knot_python_semantic/resources/mdtest/type_properties/is_disjoint_from.md
+++ b/crates/red_knot_python_semantic/resources/mdtest/type_properties/is_disjoint_from.md
@@ -61,7 +61,7 @@ static_assert(is_disjoint_from(B2, FinalSubclass))
 ## Tuple types
 
 ```py
-from typing_extensions import Literal
+from typing_extensions import Literal, Never
 from knot_extensions import TypeOf, is_disjoint_from, static_assert
 
 static_assert(is_disjoint_from(tuple[()], TypeOf[object]))
@@ -353,3 +353,29 @@ class UsesMeta2(metaclass=Meta2): ...
 
 static_assert(is_disjoint_from(type[UsesMeta1], type[UsesMeta2]))
 ```
+
+## Callables
+
+No two callable types are disjoint because there exists a non-empty callable type
+`(*args: object, **kwargs: object) -> Never` that is a subtype of all fully static callable types.
+As such, for any two callable types, it is possible to conceive of a runtime callable object that
+would inhabit both types simultaneously.
+
+```py
+from knot_extensions import CallableTypeOf, is_disjoint_from, static_assert
+from typing_extensions import Callable, Literal, Never
+
+def mixed(a: int, /, b: str, *args: int, c: int = 2, **kwargs: int) -> None: ...
+
+static_assert(not is_disjoint_from(Callable[[], Never], CallableTypeOf[mixed]))
+static_assert(not is_disjoint_from(Callable[[int, str], float], CallableTypeOf[mixed]))
+
+# Using gradual form
+static_assert(not is_disjoint_from(Callable[..., None], Callable[[], None]))
+static_assert(not is_disjoint_from(Callable[..., None], Callable[..., None]))
+static_assert(not is_disjoint_from(Callable[..., None], Callable[[Literal[1]], None]))
+
+# Using `Never`
+static_assert(not is_disjoint_from(Callable[[], Never], Callable[[], Never]))
+static_assert(not is_disjoint_from(Callable[[Never], str], Callable[[Never], int]))
+```
diff --git a/crates/red_knot_python_semantic/src/types.rs b/crates/red_knot_python_semantic/src/types.rs
index f81d92a6e6..7cd2a9ebc7 100644
--- a/crates/red_knot_python_semantic/src/types.rs
+++ b/crates/red_knot_python_semantic/src/types.rs
@@ -1343,6 +1343,19 @@ impl<'db> Type<'db> {
                 .to_instance(db)
                 .is_disjoint_from(db, other),
 
+            (Type::Callable(_) | Type::FunctionLiteral(_), Type::Callable(_))
+            | (Type::Callable(_), Type::FunctionLiteral(_)) => {
+                // No two callable types are ever disjoint because
+                // `(*args: object, **kwargs: object) -> Never` is a subtype of all fully static
+                // callable types.
+                false
+            }
+
+            (Type::Callable(_), _) | (_, Type::Callable(_)) => {
+                // TODO: Implement disjointness for general callable type with other types
+                false
+            }
+
             (Type::ModuleLiteral(..), other @ Type::Instance(..))
             | (other @ Type::Instance(..), Type::ModuleLiteral(..)) => {
                 // Modules *can* actually be instances of `ModuleType` subclasses
@@ -1379,11 +1392,6 @@ impl<'db> Type<'db> {
                 // TODO: add checks for the above cases once we support them
                 instance.is_disjoint_from(db, KnownClass::Tuple.to_instance(db))
             }
-
-            (Type::Callable(_), _) | (_, Type::Callable(_)) => {
-                // TODO: Implement disjointedness for callable types
-                false
-            }
         }
     }