diff --git a/crates/ty_python_semantic/resources/mdtest/call/replace.md b/crates/ty_python_semantic/resources/mdtest/call/replace.md
index 8d5a6b55bd..43e59bdf79 100644
--- a/crates/ty_python_semantic/resources/mdtest/call/replace.md
+++ b/crates/ty_python_semantic/resources/mdtest/call/replace.md
@@ -71,3 +71,38 @@ e = a.__replace__(x="wrong")  # error: [invalid-argument-type]
 # TODO: this should ideally also be emit an error
 e = replace(a, x="wrong")
 ```
+
+### NamedTuples
+
+NamedTuples also support the `__replace__` protocol:
+
+```py
+from typing import NamedTuple
+from copy import replace
+
+class Point(NamedTuple):
+    x: int
+    y: int
+
+reveal_type(Point.__replace__)  # revealed: (self: Self, *, x: int = ..., y: int = ...) -> Self
+```
+
+The `__replace__` method can either be called directly or through the `replace` function:
+
+```py
+a = Point(1, 2)
+
+b = a.__replace__(x=3, y=4)
+reveal_type(b)  # revealed: Point
+
+b = replace(a, x=3, y=4)
+# TODO: this should be `Point`, once we support specialization of generic protocols
+reveal_type(b)  # revealed: Unknown
+```
+
+Invalid calls to `__replace__` will raise an error:
+
+```py
+# error: [unknown-argument] "Argument `z` does not match any known parameter"
+a.__replace__(z=42)
+```
diff --git a/crates/ty_python_semantic/resources/mdtest/named_tuple.md b/crates/ty_python_semantic/resources/mdtest/named_tuple.md
index 5fd71b988b..56cbb263bf 100644
--- a/crates/ty_python_semantic/resources/mdtest/named_tuple.md
+++ b/crates/ty_python_semantic/resources/mdtest/named_tuple.md
@@ -269,7 +269,7 @@ reveal_type(Person._field_defaults)  # revealed: dict[str, Any]
 reveal_type(Person._fields)  # revealed: tuple[str, ...]
 reveal_type(Person._make)  # revealed: bound method <class 'Person'>._make(iterable: Iterable[Any]) -> Person
 reveal_type(Person._asdict)  # revealed: def _asdict(self) -> dict[str, Any]
-reveal_type(Person._replace)  # revealed: def _replace(self, **kwargs: Any) -> Self@_replace
+reveal_type(Person._replace)  # revealed: (self: Self, *, name: str = ..., age: int | None = ...) -> Self
 
 reveal_type(Person._make(("Alice", 42)))  # revealed: Person
 
@@ -277,6 +277,10 @@ person = Person("Alice", 42)
 
 reveal_type(person._asdict())  # revealed: dict[str, Any]
 reveal_type(person._replace(name="Bob"))  # revealed: Person
+
+# Invalid keyword arguments are detected:
+# error: [unknown-argument] "Argument `invalid` does not match any known parameter"
+person._replace(invalid=42)
 ```
 
 When accessing them on child classes of generic `NamedTuple`s, the return type is specialized
@@ -343,7 +347,7 @@ satisfy:
 def expects_named_tuple(x: typing.NamedTuple):
     reveal_type(x)  # revealed: tuple[object, ...] & NamedTupleLike
     reveal_type(x._make)  # revealed: bound method type[NamedTupleLike]._make(iterable: Iterable[Any]) -> NamedTupleLike
-    reveal_type(x._replace)  # revealed: bound method NamedTupleLike._replace(**kwargs) -> NamedTupleLike
+    reveal_type(x._replace)  # revealed: bound method NamedTupleLike._replace(...) -> NamedTupleLike
     # revealed: Overload[(value: tuple[object, ...], /) -> tuple[object, ...], (value: tuple[_T@__add__, ...], /) -> tuple[object, ...]]
     reveal_type(x.__add__)
     reveal_type(x.__iter__)  # revealed: bound method tuple[object, ...].__iter__() -> Iterator[object]
@@ -355,8 +359,9 @@ def _(y: type[typing.NamedTuple]):
 def _(z: typing.NamedTuple[int]): ...
 ```
 
-Any instance of a `NamedTuple` class can therefore be passed for a function parameter that is
-annotated with `NamedTuple`:
+NamedTuples are assignable to `NamedTupleLike`. The `NamedTupleLike._replace` method is typed with
+`(*args, **kwargs)`, which type checkers treat as equivalent to `...` (per the typing spec), making
+all NamedTuple implementations automatically compatible:
 
 ```py
 from typing import NamedTuple, Protocol, Iterable, Any
@@ -368,12 +373,15 @@ class Point(NamedTuple):
 
 reveal_type(Point._make)  # revealed: bound method <class 'Point'>._make(iterable: Iterable[Any]) -> Point
 reveal_type(Point._asdict)  # revealed: def _asdict(self) -> dict[str, Any]
-reveal_type(Point._replace)  # revealed: def _replace(self, **kwargs: Any) -> Self@_replace
+reveal_type(Point._replace)  # revealed: (self: Self, *, x: int = ..., y: int = ...) -> Self
 
+# Point is assignable to NamedTuple.
 static_assert(is_assignable_to(Point, NamedTuple))
 
-expects_named_tuple(Point(x=42, y=56))  # fine
+# NamedTuple instances can be passed to functions expecting NamedTupleLike.
+expects_named_tuple(Point(x=42, y=56))
 
+# But plain tuples are not NamedTupleLike (they don't have _make, _asdict, _replace, etc.).
 # error: [invalid-argument-type] "Argument to function `expects_named_tuple` is incorrect: Expected `tuple[object, ...] & NamedTupleLike`, found `tuple[Literal[1], Literal[2]]`"
 expects_named_tuple((1, 2))
 ```
diff --git a/crates/ty_python_semantic/src/types/class.rs b/crates/ty_python_semantic/src/types/class.rs
index 9a941a913b..d5e26b6b57 100644
--- a/crates/ty_python_semantic/src/types/class.rs
+++ b/crates/ty_python_semantic/src/types/class.rs
@@ -35,13 +35,13 @@ use crate::types::tuple::{TupleSpec, TupleType};
 use crate::types::typed_dict::typed_dict_params_from_class_def;
 use crate::types::visitor::{TypeCollector, TypeVisitor, walk_type_with_recursion_guard};
 use crate::types::{
-    ApplyTypeMappingVisitor, Binding, BoundSuperType, CallableType, CallableTypeKind,
-    CallableTypes, DATACLASS_FLAGS, DataclassFlags, DataclassParams, DeprecatedInstance,
-    FindLegacyTypeVarsVisitor, HasRelationToVisitor, IsDisjointVisitor, IsEquivalentVisitor,
-    KnownInstanceType, ManualPEP695TypeAliasType, MaterializationKind, NormalizedVisitor,
-    PropertyInstanceType, StringLiteralType, TypeAliasType, TypeContext, TypeMapping, TypeRelation,
-    TypedDictParams, UnionBuilder, VarianceInferable, binding_type, declaration_type,
-    determine_upper_bound,
+    ApplyTypeMappingVisitor, Binding, BindingContext, BoundSuperType, CallableType,
+    CallableTypeKind, CallableTypes, DATACLASS_FLAGS, DataclassFlags, DataclassParams,
+    DeprecatedInstance, FindLegacyTypeVarsVisitor, HasRelationToVisitor, IsDisjointVisitor,
+    IsEquivalentVisitor, KnownInstanceType, ManualPEP695TypeAliasType, MaterializationKind,
+    NormalizedVisitor, PropertyInstanceType, StringLiteralType, TypeAliasType, TypeContext,
+    TypeMapping, TypeRelation, TypedDictParams, UnionBuilder, VarianceInferable, binding_type,
+    declaration_type, determine_upper_bound,
 };
 use crate::{
     Db, FxIndexMap, FxIndexSet, FxOrderSet, Program,
@@ -2507,7 +2507,8 @@ impl<'db> ClassLiteral<'db> {
                     }
                 }
 
-                let is_kw_only = name == "__replace__" || kw_only.unwrap_or(false);
+                let is_kw_only =
+                    matches!(name, "__replace__" | "_replace") || kw_only.unwrap_or(false);
 
                 // Use the alias name if provided, otherwise use the field name
                 let parameter_name =
@@ -2520,7 +2521,7 @@ impl<'db> ClassLiteral<'db> {
                 }
                 .with_annotated_type(field_ty);
 
-                if name == "__replace__" {
+                if matches!(name, "__replace__" | "_replace") {
                     // When replacing, we know there is a default value for the field
                     // (the value that is currently assigned to the field)
                     // assume this to be the declared type of the field
@@ -2563,6 +2564,25 @@ impl<'db> ClassLiteral<'db> {
                     .with_annotated_type(KnownClass::Type.to_instance(db));
                 signature_from_fields(vec![cls_parameter], Some(Type::none(db)))
             }
+            (CodeGeneratorKind::NamedTuple, "_replace" | "__replace__") => {
+                if name == "__replace__"
+                    && Program::get(db).python_version(db) < PythonVersion::PY313
+                {
+                    return None;
+                }
+                // Use `Self` type variable as return type so that subclasses get the correct
+                // return type when calling `_replace`. For example, if `IntBox` inherits from
+                // `Box[int]` (a NamedTuple), then `IntBox(1)._replace(content=42)` should return
+                // `IntBox`, not `Box[int]`.
+                let self_ty = Type::TypeVar(BoundTypeVarInstance::synthetic_self(
+                    db,
+                    instance_ty,
+                    BindingContext::Synthetic,
+                ));
+                let self_parameter = Parameter::positional_or_keyword(Name::new_static("self"))
+                    .with_annotated_type(self_ty);
+                signature_from_fields(vec![self_parameter], Some(self_ty))
+            }
             (CodeGeneratorKind::DataclassLike(_), "__lt__" | "__le__" | "__gt__" | "__ge__") => {
                 if !has_dataclass_param(DataclassFlags::ORDER) {
                     return None;
diff --git a/crates/ty_vendored/ty_extensions/ty_extensions.pyi b/crates/ty_vendored/ty_extensions/ty_extensions.pyi
index 347b6b4b34..ed0bf16186 100644
--- a/crates/ty_vendored/ty_extensions/ty_extensions.pyi
+++ b/crates/ty_vendored/ty_extensions/ty_extensions.pyi
@@ -190,6 +190,16 @@ class NamedTupleLike(Protocol):
     @classmethod
     def _make(cls: type[Self], iterable: Iterable[Any]) -> Self: ...
     def _asdict(self, /) -> dict[str, Any]: ...
-    def _replace(self, /, **kwargs) -> Self: ...
+
+    # Positional arguments aren't actually accepted by these methods at runtime,
+    # but adding the `*args` parameters means that all `NamedTuple` classes
+    # are understood as assignable to this protocol due to the special case
+    # outlined in https://typing.python.org/en/latest/spec/callables.html#meaning-of-in-callable:
+    #
+    # > If the input signature in a function definition includes both a
+    # > `*args` and `**kwargs` parameter and both are typed as `Any`
+    # > (explicitly or implicitly because it has no annotation), a type
+    # > checker should treat this as the equivalent of `...`.
+    def _replace(self, *args, **kwargs) -> Self: ...
     if sys.version_info >= (3, 13):
-        def __replace__(self, **kwargs) -> Self: ...
+        def __replace__(self, *args, **kwargs) -> Self: ...