diff --git a/crates/ruff_linter/resources/test/fixtures/refurb/FURB181.py b/crates/ruff_linter/resources/test/fixtures/refurb/FURB181.py
index 559f67ee30..5c178cdcd3 100644
--- a/crates/ruff_linter/resources/test/fixtures/refurb/FURB181.py
+++ b/crates/ruff_linter/resources/test/fixtures/refurb/FURB181.py
@@ -55,3 +55,12 @@ class Hash:
 
 
 Hash().digest().hex()
+
+
+hashed = (
+    sha512(b"some data")
+    .digest(
+        # text
+    )
+    .hex()
+)
\ No newline at end of file
diff --git a/crates/ruff_linter/src/rules/refurb/rules/hashlib_digest_hex.rs b/crates/ruff_linter/src/rules/refurb/rules/hashlib_digest_hex.rs
index deac83a9d0..4365053279 100644
--- a/crates/ruff_linter/src/rules/refurb/rules/hashlib_digest_hex.rs
+++ b/crates/ruff_linter/src/rules/refurb/rules/hashlib_digest_hex.rs
@@ -1,3 +1,4 @@
+use ruff_diagnostics::Applicability;
 use ruff_macros::{ViolationMetadata, derive_message_formats};
 use ruff_python_ast::{Expr, ExprAttribute, ExprCall};
 use ruff_python_semantic::Modules;
@@ -28,6 +29,9 @@ use crate::{Edit, Fix, FixAvailability, Violation};
 /// hashed = sha512(b"some data").hexdigest()
 /// ```
 ///
+/// ## Fix safety
+/// This rule's fix is marked as safe, unless the expression contains comments.
+///
 /// ## References
 /// - [Python documentation: `hashlib`](https://docs.python.org/3/library/hashlib.html)
 #[derive(ViolationMetadata)]
@@ -112,10 +116,18 @@ pub(crate) fn hashlib_digest_hex(checker: &Checker, call: &ExprCall) {
     {
         let mut diagnostic = checker.report_diagnostic(HashlibDigestHex, call.range());
         if arguments.is_empty() {
-            diagnostic.set_fix(Fix::safe_edit(Edit::range_replacement(
-                ".hexdigest".to_string(),
-                TextRange::new(value.end(), call.func.end()),
-            )));
+            let replacement_range = TextRange::new(value.end(), call.func.end());
+
+            let applicability = if checker.comment_ranges().intersects(replacement_range) {
+                Applicability::Unsafe
+            } else {
+                Applicability::Safe
+            };
+
+            diagnostic.set_fix(Fix::applicable_edit(
+                Edit::range_replacement(".hexdigest".to_string(), replacement_range),
+                applicability,
+            ));
         }
     }
 }
diff --git a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB181_FURB181.py.snap b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB181_FURB181.py.snap
index d437b1ae07..384a5f8359 100644
--- a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB181_FURB181.py.snap
+++ b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB181_FURB181.py.snap
@@ -322,3 +322,28 @@ help: Replace with `.hexdigest()`
 39 | 
 40 | # not yet supported
 41 | h = sha256()
+
+FURB181 [*] Use of hashlib's `.digest().hex()`
+  --> FURB181.py:61:5
+   |
+60 |   hashed = (
+61 | /     sha512(b"some data")
+62 | |     .digest(
+63 | |         # text
+64 | |     )
+65 | |     .hex()
+   | |__________^
+66 |   )
+   |
+help: Replace with `.hexdigest()`
+58 | 
+59 | 
+60 | hashed = (
+   -     sha512(b"some data")
+   -     .digest(
+   -         # text
+   -     )
+   -     .hex()
+61 +     sha512(b"some data").hexdigest()
+62 | )
+note: This is an unsafe fix and may change runtime behavior