diff --git a/Cargo.lock b/Cargo.lock
index fdd98f432..6d886e80f 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -4376,6 +4376,7 @@ dependencies = [
  "itertools 0.13.0",
  "jiff",
  "miette",
+ "nix",
  "owo-colors",
  "petgraph",
  "predicates",
@@ -5798,7 +5799,7 @@ version = "0.1.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "cf221c93e13a30d793f7645a0e7762c55d169dbb0a49671918a2319d289b10bb"
 dependencies = [
- "windows-sys 0.48.0",
+ "windows-sys 0.59.0",
 ]
 
 [[package]]
diff --git a/Cargo.toml b/Cargo.toml
index 3075f6793..f055ca98e 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -120,15 +120,15 @@ md-5 = { version = "0.10.6" }
 memchr = { version = "2.7.4" }
 miette = { version = "7.2.0" }
 nanoid = { version = "0.4.0" }
+nix = { version = "0.29.0" }
 owo-colors = { version = "4.1.0" }
 path-slash = { version = "0.2.1" }
 pathdiff = { version = "0.2.1" }
 petgraph = { version = "0.6.5" }
 platform-info = { version = "2.0.3" }
-procfs = { version = "0.17.0", default-features = false, features = ["flate2"] }
 proc-macro2 = { version = "1.0.86" }
+procfs = { version = "0.17.0", default-features = false, features = ["flate2"] }
 pubgrub = { git = "https://github.com/astral-sh/pubgrub", rev = "95e1390399cdddee986b658be19587eb1fdb2d79" }
-version-ranges = { git = "https://github.com/astral-sh/pubgrub", rev = "95e1390399cdddee986b658be19587eb1fdb2d79" }
 quote = { version = "1.0.37" }
 rayon = { version = "1.10.0" }
 reflink-copy = { version = "0.1.19" }
@@ -172,6 +172,7 @@ unicode-width = { version = "0.1.13" }
 unscanny = { version = "0.1.0" }
 url = { version = "2.5.2" }
 urlencoding = { version = "2.1.3" }
+version-ranges = { git = "https://github.com/astral-sh/pubgrub", rev = "95e1390399cdddee986b658be19587eb1fdb2d79" }
 walkdir = { version = "2.5.0" }
 which = { version = "7.0.0", features = ["regex"] }
 windows-registry = { version = "0.3.0" }
diff --git a/crates/uv/Cargo.toml b/crates/uv/Cargo.toml
index b2be62851..1d0af552e 100644
--- a/crates/uv/Cargo.toml
+++ b/crates/uv/Cargo.toml
@@ -115,6 +115,9 @@ similar = { version = "2.6.0" }
 tempfile = { workspace = true }
 zip = { workspace = true }
 
+[target.'cfg(unix)'.dependencies]
+nix = { workspace = true }
+
 [package.metadata.cargo-shear]
 ignored = [
     "flate2",
diff --git a/crates/uv/src/commands/project/run.rs b/crates/uv/src/commands/project/run.rs
index 76c759cb9..6ce8bcbcc 100644
--- a/crates/uv/src/commands/project/run.rs
+++ b/crates/uv/src/commands/project/run.rs
@@ -996,9 +996,30 @@ pub(crate) async fn run(
     // signal handlers after the command completes.
     let _handler = tokio::spawn(async { while tokio::signal::ctrl_c().await.is_ok() {} });
 
-    let status = handle.wait().await.context("Child process disappeared")?;
+    // Exit based on the result of the command.
+    #[cfg(unix)]
+    let status = {
+        use tokio::select;
+        use tokio::signal::unix::{signal, SignalKind};
+
+        let mut term_signal = signal(SignalKind::terminate())?;
+        loop {
+            select! {
+                result = handle.wait() => {
+                    break result;
+                },
+
+                // `SIGTERM`
+                _ = term_signal.recv() => {
+                    let _ = terminate_process(&mut handle);
+                }
+            };
+        }
+    }?;
+
+    #[cfg(not(unix))]
+    let status = handle.wait().await?;
 
-    // Exit based on the result of the command
     if let Some(code) = status.code() {
         debug!("Command exited with code: {code}");
         if let Ok(code) = u8::try_from(code) {
@@ -1017,6 +1038,15 @@ pub(crate) async fn run(
     }
 }
 
+#[cfg(unix)]
+fn terminate_process(child: &mut tokio::process::Child) -> anyhow::Result<()> {
+    use nix::sys::signal::{self, Signal};
+    use nix::unistd::Pid;
+
+    let pid = child.id().context("Failed to get child process ID")?;
+    signal::kill(Pid::from_raw(pid.try_into()?), Signal::SIGTERM).context("Failed to send SIGTERM")
+}
+
 /// Returns `true` if we can skip creating an additional ephemeral environment in `uv run`.
 fn can_skip_ephemeral(
     spec: Option<&RequirementsSpecification>,
diff --git a/crates/uv/src/commands/tool/run.rs b/crates/uv/src/commands/tool/run.rs
index 43816a5d7..16062ccc9 100644
--- a/crates/uv/src/commands/tool/run.rs
+++ b/crates/uv/src/commands/tool/run.rs
@@ -236,9 +236,30 @@ pub(crate) async fn run(
     // signal handlers after the command completes.
     let _handler = tokio::spawn(async { while tokio::signal::ctrl_c().await.is_ok() {} });
 
-    let status = handle.wait().await.context("Child process disappeared")?;
+    // Exit based on the result of the command.
+    #[cfg(unix)]
+    let status = {
+        use tokio::select;
+        use tokio::signal::unix::{signal, SignalKind};
+
+        let mut term_signal = signal(SignalKind::terminate())?;
+        loop {
+            select! {
+                result = handle.wait() => {
+                    break result;
+                },
+
+                // `SIGTERM`
+                _ = term_signal.recv() => {
+                    let _ = terminate_process(&mut handle);
+                }
+            };
+        }
+    }?;
+
+    #[cfg(not(unix))]
+    let status = handle.wait().await?;
 
-    // Exit based on the result of the command
     if let Some(code) = status.code() {
         debug!("Command exited with code: {code}");
         if let Ok(code) = u8::try_from(code) {
@@ -257,6 +278,15 @@ pub(crate) async fn run(
     }
 }
 
+#[cfg(unix)]
+fn terminate_process(child: &mut tokio::process::Child) -> anyhow::Result<()> {
+    use nix::sys::signal::{self, Signal};
+    use nix::unistd::Pid;
+
+    let pid = child.id().context("Failed to get child process ID")?;
+    signal::kill(Pid::from_raw(pid.try_into()?), Signal::SIGTERM).context("Failed to send SIGTERM")
+}
+
 /// Return the entry points for the specified package.
 fn get_entrypoints(
     from: &PackageName,