diff --git a/crates/puffin-cli/src/commands/pip_compile.rs b/crates/puffin-cli/src/commands/pip_compile.rs
index d49c0ebc5..54aae4848 100644
--- a/crates/puffin-cli/src/commands/pip_compile.rs
+++ b/crates/puffin-cli/src/commands/pip_compile.rs
@@ -124,16 +124,14 @@ pub(crate) async fn pip_compile(
     // Determine the compatible platform tags.
     let tags = Tags::from_interpreter(venv.interpreter())?;
 
+    // Determine the interpreter to use for resolution.
+    let interpreter = venv.interpreter().clone();
+
     // Determine the markers to use for resolution.
     let markers = python_version.map_or_else(
         || Cow::Borrowed(venv.interpreter().markers()),
         |python_version| Cow::Owned(python_version.markers(venv.interpreter().markers())),
     );
-    // Inject the fake python version if necessary
-    let interpreter_info = venv
-        .interpreter()
-        .clone()
-        .patch_markers(markers.clone().into_owned());
 
     // Instantiate a client.
     let client = RegistryClientBuilder::new(cache.clone())
@@ -143,7 +141,7 @@ pub(crate) async fn pip_compile(
     let build_dispatch = BuildDispatch::new(
         client.clone(),
         cache.clone(),
-        interpreter_info,
+        interpreter,
         fs::canonicalize(venv.python_executable())?,
         no_build,
         index_urls,
diff --git a/crates/puffin-interpreter/src/interpreter.rs b/crates/puffin-interpreter/src/interpreter.rs
index 734f261cd..e17572263 100644
--- a/crates/puffin-interpreter/src/interpreter.rs
+++ b/crates/puffin-interpreter/src/interpreter.rs
@@ -95,12 +95,6 @@ impl Interpreter {
     pub fn sys_executable(&self) -> &Path {
         &self.sys_executable
     }
-
-    /// Inject markers of a fake python version
-    #[must_use]
-    pub fn patch_markers(self, markers: MarkerEnvironment) -> Self {
-        Self { markers, ..self }
-    }
 }
 
 #[derive(Debug, Deserialize, Serialize, Clone)]
diff --git a/crates/puffin-resolver/src/resolver.rs b/crates/puffin-resolver/src/resolver.rs
index 5bea25b2e..13f195833 100644
--- a/crates/puffin-resolver/src/resolver.rs
+++ b/crates/puffin-resolver/src/resolver.rs
@@ -551,7 +551,8 @@ impl<'a, Context: BuildContext + Send + Sync> Resolver<'a, Context> {
                         metadata,
                         &package_name,
                         self.tags,
-                        self.build_context.interpreter().version(),
+                        self.markers,
+                        self.build_context.interpreter(),
                         self.exclude_newer.as_ref(),
                     );
                     self.index
diff --git a/crates/puffin-resolver/src/version_map.rs b/crates/puffin-resolver/src/version_map.rs
index b61a2f785..772f075e7 100644
--- a/crates/puffin-resolver/src/version_map.rs
+++ b/crates/puffin-resolver/src/version_map.rs
@@ -6,8 +6,9 @@ use chrono::{DateTime, Utc};
 use tracing::warn;
 
 use distribution_filename::{SourceDistFilename, WheelFilename};
-use pep440_rs::Version;
+use pep508_rs::MarkerEnvironment;
 use platform_tags::{TagPriority, Tags};
+use puffin_interpreter::Interpreter;
 use puffin_macros::warn_once;
 use puffin_normalize::PackageName;
 use pypi_types::{SimpleJson, Yanked};
@@ -25,7 +26,8 @@ impl VersionMap {
         metadata: SimpleJson,
         package_name: &PackageName,
         tags: &Tags,
-        python_version: &Version,
+        markers: &MarkerEnvironment,
+        interpreter: &Interpreter,
         exclude_newer: Option<&DateTime<Utc>>,
     ) -> Self {
         let mut version_map: BTreeMap<PubGrubVersion, PrioritizedDistribution> =
@@ -38,14 +40,17 @@ impl VersionMap {
             // distributions which give no other indication of their compatibility and wheels which
             // may be tagged `py3-none-any` but have `requires-python: ">=3.9"`.
             // TODO(konstin): https://github.com/astral-sh/puffin/issues/406
-            if !file
-                .requires_python
-                .as_ref()
-                .map_or(true, |requires_python| {
-                    requires_python.contains(python_version)
-                })
-            {
-                continue;
+            if let Some(requires_python) = file.requires_python.as_ref() {
+                // The interpreter and marker version are often the same, but can differ. For
+                // example, if the user is resolving against a target Python version passed in
+                // via the command-line, that version will differ from the interpreter version.
+                let interpreter_version = interpreter.version();
+                let marker_version = &markers.python_version.version;
+                if !requires_python.contains(interpreter_version)
+                    || !requires_python.contains(marker_version)
+                {
+                    continue;
+                }
             }
 
             // Support resolving as if it were an earlier timestamp, at least as long files have