diff --git a/crates/uv-performance-flate2-backend/Cargo.lock b/crates/uv-performance-flate2-backend/Cargo.lock
index 718b75bef..3799c814f 100644
--- a/crates/uv-performance-flate2-backend/Cargo.lock
+++ b/crates/uv-performance-flate2-backend/Cargo.lock
@@ -8,12 +8,30 @@ version = "2.0.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "512761e0bb2578dd7380c6baaa0f4ce03e84f95e960231d1dec8bf4d7d6e2627"
 
+[[package]]
+name = "cc"
+version = "1.2.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a012a0df96dd6d06ba9a1b29d6402d1a5d77c6befd2566afdc26e10603dc93d7"
+dependencies = [
+ "shlex",
+]
+
 [[package]]
 name = "cfg-if"
 version = "1.0.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "baf1de4339761588bc0619e3cbc0120ee582ebb74b53b4efbf79117bd2da40fd"
 
+[[package]]
+name = "cmake"
+version = "0.1.52"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c682c223677e0e5b6b7f63a64b9351844c3f1b1678a68b7ee617e30fb082620e"
+dependencies = [
+ "cc",
+]
+
 [[package]]
 name = "crc32fast"
 version = "1.4.2"
@@ -30,10 +48,27 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "c936bfdafb507ebbf50b8074c54fa31c5be9a1e7e5f467dd659697041407d07c"
 dependencies = [
  "crc32fast",
+ "libz-ng-sys",
  "libz-rs-sys",
  "miniz_oxide",
 ]
 
+[[package]]
+name = "libc"
+version = "0.2.169"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b5aba8db14291edd000dfcc4d620c7ebfb122c613afb886ca8803fa4e128a20a"
+
+[[package]]
+name = "libz-ng-sys"
+version = "1.1.16"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4436751a01da56f1277f323c80d584ffad94a3d14aecd959dd0dff75aa73a438"
+dependencies = [
+ "cmake",
+ "libc",
+]
+
 [[package]]
 name = "libz-rs-sys"
 version = "0.4.1"
@@ -52,11 +87,18 @@ dependencies = [
  "adler2",
 ]
 
+[[package]]
+name = "shlex"
+version = "1.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0fda2ff0d084019ba4d7c6f371c95d8fd75ce3524c3cb8fb653a3023f6323e64"
+
 [[package]]
 name = "uv-performance-flate2-backend"
 version = "0.1.0"
 dependencies = [
  "flate2",
+ "libz-ng-sys",
 ]
 
 [[package]]
diff --git a/crates/uv-performance-flate2-backend/Cargo.toml b/crates/uv-performance-flate2-backend/Cargo.toml
index 7f137bfe6..61249be4e 100644
--- a/crates/uv-performance-flate2-backend/Cargo.toml
+++ b/crates/uv-performance-flate2-backend/Cargo.toml
@@ -7,12 +7,12 @@ edition = "2021"
 [lib]
 doctest = false
 
-# Use `zlib-ng` on x86_64 targets, apart from FreeBSD.
-[target.'cfg(all(target_arch = "x86_64", not(target_os = "freebsd")))'.dependencies]
+# Use `zlib-ng` on all supported platforms.
+[target.'cfg(not(any(target_arch = "s390x", target_arch = "powerpc64", target_os = "freebsd")))'.dependencies]
 flate2 = { version = "1.0.28", default-features = false, features = ["zlib-ng"] }
 # See: https://github.com/rust-lang/libz-sys/issues/225
 libz-ng-sys = { version = "<1.1.20" }
 
 # Use `zlib-rs` everywhere else.
-[target.'cfg(not(all(target_arch = "x86_64", not(target_os = "freebsd"))))'.dependencies]
+[target.'cfg(any(target_arch = "s390x", target_arch = "powerpc64", target_os = "freebsd"))'.dependencies]
 flate2 = { version = "1.0.28", default-features = false, features = ["zlib-rs"] }