diff --git a/crates/gourgeist/src/bare.rs b/crates/gourgeist/src/bare.rs
index 0ebaa5852..fac848f53 100644
--- a/crates/gourgeist/src/bare.rs
+++ b/crates/gourgeist/src/bare.rs
@@ -191,7 +191,8 @@ pub fn create_bare_venv(
             .replace(
                 "{{ RELATIVE_SITE_PACKAGES }}",
                 &format!(
-                    "../lib/python{}.{}/site-packages",
+                    "../lib/{}{}.{}/site-packages",
+                    interpreter.site_packages_python(),
                     interpreter.python_major(),
                     interpreter.python_minor(),
                 ),
@@ -278,7 +279,8 @@ pub fn create_bare_venv(
         location
             .join("lib")
             .join(format!(
-                "python{}.{}",
+                "{}{}.{}",
+                interpreter.site_packages_python(),
                 interpreter.python_major(),
                 interpreter.python_minor(),
             ))
diff --git a/crates/uv-interpreter/src/interpreter.rs b/crates/uv-interpreter/src/interpreter.rs
index 3f0d16ad6..f9ebce00c 100644
--- a/crates/uv-interpreter/src/interpreter.rs
+++ b/crates/uv-interpreter/src/interpreter.rs
@@ -93,9 +93,21 @@ impl Interpreter {
             // structure, which allows us to avoid querying the interpreter for the `sysconfig`
             // paths.
             sysconfig_paths: SysconfigPaths {
-                purelib: layout.site_packages(&venv_root, self.python_tuple()),
-                platlib: layout.site_packages(&venv_root, self.python_tuple()),
-                platstdlib: layout.platstdlib(&venv_root, self.python_tuple()),
+                purelib: layout.site_packages(
+                    &venv_root,
+                    self.site_packages_python(),
+                    self.python_tuple(),
+                ),
+                platlib: layout.site_packages(
+                    &venv_root,
+                    self.site_packages_python(),
+                    self.python_tuple(),
+                ),
+                platstdlib: layout.platstdlib(
+                    &venv_root,
+                    self.site_packages_python(),
+                    self.python_tuple(),
+                ),
                 scripts: layout.scripts(&venv_root),
                 data: layout.data(&venv_root),
                 ..self.sysconfig_paths
@@ -399,6 +411,33 @@ impl Interpreter {
         &self.sysconfig_paths.stdlib
     }
 
+    /// Return the name of the Python directory used to build the path to the
+    /// `site-packages` directory.
+    ///
+    /// If one could not be determined, then `python` is returned.
+    pub fn site_packages_python(&self) -> &str {
+        if self.implementation_name() == "pypy" {
+            "pypy"
+        } else {
+            "python"
+        }
+
+        // This implementation sniffs out what the directory name
+        // might be from sysconfig, but at the time of writing, this
+        // seems a little more risky than the simpler but less robust
+        // implementation above.
+        /*
+        const FALLBACK: &str = "python";
+        let Some(base) = self.include().file_name().and_then(|name| name.to_str()) else {
+            return FALLBACK;
+        };
+        base.char_indices()
+            .take_while(|(_, ch)| ch.is_ascii_alphabetic())
+            .last()
+            .map_or(FALLBACK, |(end, ch)| &base[..end + ch.len_utf8()])
+        */
+    }
+
     /// Return the [`Layout`] environment used to install wheels into this interpreter.
     pub fn layout(&self) -> Layout {
         Layout {
@@ -412,7 +451,8 @@ impl Interpreter {
                 // If the interpreter is a venv, then the `include` directory has a different structure.
                 // See: https://github.com/pypa/pip/blob/0ad4c94be74cc24874c6feb5bb3c2152c398a18e/src/pip/_internal/locations/_sysconfig.py#L172
                 self.prefix.join("include").join("site").join(format!(
-                    "python{}.{}",
+                    "{}{}.{}",
+                    self.site_packages_python(),
                     self.python_major(),
                     self.python_minor()
                 ))
diff --git a/crates/uv-interpreter/src/virtualenv_layout.rs b/crates/uv-interpreter/src/virtualenv_layout.rs
index 81673657b..a05535de7 100644
--- a/crates/uv-interpreter/src/virtualenv_layout.rs
+++ b/crates/uv-interpreter/src/virtualenv_layout.rs
@@ -41,13 +41,18 @@ impl<'a> VirtualenvLayout<'a> {
     }
 
     /// Returns the path to the `site-packages` directory inside a virtual environment.
-    pub(crate) fn site_packages(&self, venv_root: impl AsRef<Path>, version: (u8, u8)) -> PathBuf {
+    pub(crate) fn site_packages(
+        &self,
+        venv_root: impl AsRef<Path>,
+        site_packages_python: &str,
+        version: (u8, u8),
+    ) -> PathBuf {
         let venv = venv_root.as_ref();
         if matches!(self.0.os(), Os::Windows) {
             venv.join("Lib").join("site-packages")
         } else {
             venv.join("lib")
-                .join(format!("python{}.{}", version.0, version.1))
+                .join(format!("{site_packages_python}{}.{}", version.0, version.1))
                 .join("site-packages")
         }
     }
@@ -60,13 +65,18 @@ impl<'a> VirtualenvLayout<'a> {
 
     /// Returns the path to the `platstdlib` directory inside a virtual environment.
     #[allow(clippy::unused_self)]
-    pub(crate) fn platstdlib(&self, venv_root: impl AsRef<Path>, version: (u8, u8)) -> PathBuf {
+    pub(crate) fn platstdlib(
+        &self,
+        venv_root: impl AsRef<Path>,
+        site_packages_python: &str,
+        version: (u8, u8),
+    ) -> PathBuf {
         let venv = venv_root.as_ref();
         if matches!(self.0.os(), Os::Windows) {
             venv.join("Lib")
         } else {
             venv.join("lib")
-                .join(format!("python{}.{}", version.0, version.1))
+                .join(format!("{site_packages_python}{}.{}", version.0, version.1))
                 .join("site-packages")
         }
     }