diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 006a98ca6..61d61330c 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -740,6 +740,8 @@ jobs:
     name: "smoke test | linux"
     runs-on: ubuntu-latest
     steps:
+      - uses: actions/checkout@v4
+
       - name: "Download binary"
         uses: actions/download-artifact@cc203385981b70ca67e1cc392babf9cc229d5806 # v4.1.9
         with:
@@ -752,9 +754,10 @@ jobs:
 
       - name: "Smoke test"
         run: |
-          ./uv venv -v
-          ./uv pip install ruff -v
-          ./uvx -v ruff --version
+          ./uv run scripts/smoke-test
+
+      - name: "Test shell completions"
+        run: |
           eval "$(./uv generate-shell-completion bash)"
           eval "$(./uvx --generate-shell-completion bash)"
 
@@ -779,14 +782,7 @@ jobs:
 
       - name: "Smoke test"
         run: |
-          # Overwrite the 3.13.0 pin from the project, there are not functional
-          # musl distributions for it
-          ./uv python pin 3.13
-          ./uv venv -v
-          ./uv pip install ruff -v
-          ./uvx -v ruff --version
-          ./uv pip install numpy -v
-          ./uv run python -c "import numpy; print(numpy.__version__)"
+          ./uv run scripts/smoke-test
 
   smoke-test-macos:
     timeout-minutes: 10
@@ -794,6 +790,8 @@ jobs:
     name: "smoke test | macos"
     runs-on: macos-latest
     steps:
+      - uses: actions/checkout@v4
+
       - name: "Download binary"
         uses: actions/download-artifact@cc203385981b70ca67e1cc392babf9cc229d5806 # v4.1.9
         with:
@@ -806,9 +804,10 @@ jobs:
 
       - name: "Smoke test"
         run: |
-          ./uv venv -v
-          ./uv pip install ruff -v
-          ./uvx -v ruff --version
+          ./uv run scripts/smoke-test
+
+      - name: "Test shell completions"
+        run: |
           eval "$(./uv generate-shell-completion bash)"
           eval "$(./uvx --generate-shell-completion bash)"
 
@@ -818,6 +817,8 @@ jobs:
     name: "smoke test | windows x86_64"
     runs-on: windows-latest
     steps:
+      - uses: actions/checkout@v4
+
       - name: "Download binary"
         uses: actions/download-artifact@cc203385981b70ca67e1cc392babf9cc229d5806 # v4.1.9
         with:
@@ -826,10 +827,16 @@ jobs:
       - name: "Smoke test"
         working-directory: ${{ env.UV_WORKSPACE }}
         run: |
-          ./uv venv -v
-          ./uv pip install ruff -v
-          ./uvx -v ruff --version
+          ./uv run scripts/smoke-test
+
+      - name: "Test uv shell completions"
+        working-directory: ${{ env.UV_WORKSPACE }}
+        run: |
           (& ./uv generate-shell-completion powershell) | Out-String | Invoke-Expression
+
+      - name: "Test uvx shell completions"
+        working-directory: ${{ env.UV_WORKSPACE }}
+        run: |
           (& ./uvx --generate-shell-completion powershell) | Out-String | Invoke-Expression
 
   smoke-test-windows-aarch64:
@@ -838,6 +845,8 @@ jobs:
     name: "smoke test | windows aarch64"
     runs-on: github-windows-11-aarch64-4
     steps:
+      - uses: actions/checkout@v4
+
       - name: "Download binary"
         uses: actions/download-artifact@cc203385981b70ca67e1cc392babf9cc229d5806 # v4.1.9
         with:
@@ -846,13 +855,16 @@ jobs:
       - name: "Smoke test"
         working-directory: ${{ env.UV_WORKSPACE }}
         run: |
-          $ErrorActionPreference = "Stop"
-          $PSNativeCommandUseErrorActionPreference = $true
+          ./uv run scripts/smoke-test
 
-          ./uv venv -v
-          ./uv pip install ruff -v
-          ./uvx -v ruff --version
+      - name: "Test uv shell completions"
+        working-directory: ${{ env.UV_WORKSPACE }}
+        run: |
           (& ./uv generate-shell-completion powershell) | Out-String | Invoke-Expression
+
+      - name: "Test uvx shell completions"
+        working-directory: ${{ env.UV_WORKSPACE }}
+        run: |
           (& ./uvx --generate-shell-completion powershell) | Out-String | Invoke-Expression
 
   integration-test-conda:
diff --git a/regular_file; echo foo; # b/regular_file; echo foo; #
new file mode 100644
index 000000000..e69de29bb
diff --git a/scripts/smoke-test/__main__.py b/scripts/smoke-test/__main__.py
new file mode 100644
index 000000000..d033549ed
--- /dev/null
+++ b/scripts/smoke-test/__main__.py
@@ -0,0 +1,60 @@
+import os
+import pathlib
+import shlex
+import subprocess
+import sys
+
+SELF_FILE = pathlib.Path(__file__)
+COMMANDS_FILE = SELF_FILE.parent / "commands.sh"
+
+
+def read_commands() -> list[list[str]]:
+    return [
+        shlex.split(line)
+        for line in COMMANDS_FILE.read_text().splitlines()
+        # Skip empty lines and comments
+        if line.strip() and not line.strip().startswith("#")
+    ]
+
+
+def run_command(command: list[str]) -> subprocess.CompletedProcess:
+    env = os.environ.copy()
+    # Prepend either the parent uv path to the PATH or the current directory
+    env = {
+        **env,
+        "PATH": str(
+            pathlib.Path(env.get("UV")).parent if "UV" in env else pathlib.Path.cwd()
+        )
+        + os.pathsep
+        + env.get("PATH"),
+    }
+    return subprocess.run(command, capture_output=True, text=True, env=env)
+
+
+def report_result(result: subprocess.CompletedProcess):
+    print("=============================================")
+    print(f"command: {' '.join(result.args)}")
+    print(f"exit code: {result.returncode}")
+    print()
+    print("------- stdout -------")
+    print(result.stdout)
+    print()
+    print("------- stderr -------")
+    print(result.stderr)
+
+
+def main():
+    results = [run_command(command) for command in read_commands()]
+    failed = sum(result.returncode != 0 for result in results)
+    for result in results:
+        report_result(result)
+
+    print("=============================================")
+    if failed:
+        print(f"FAILURE - {failed}/{len(results)} commands failed")
+        sys.exit(1)
+    else:
+        print(f"SUCCESS - {len(results)}/{len(results)} commands succeeded")
+
+
+main()
diff --git a/scripts/smoke-test/commands.sh b/scripts/smoke-test/commands.sh
new file mode 100644
index 000000000..e8c512836
--- /dev/null
+++ b/scripts/smoke-test/commands.sh
@@ -0,0 +1,17 @@
+# NOTE this is not a real shell-script, it's parsed by `smoke-test/__main__.py` and executed
+# serially via Python for cross-platform support.
+
+# Use any Python 3.13 version
+uv python pin 3.13
+
+# Create a virtual environment and install a package with `uv pip`
+uv venv -v
+uv pip install ruff -v
+
+# Install a package with extension modules, e.g., `numpy` and make sure it's importable
+uv pip install numpy -v
+uv run python -c "import numpy; print(numpy.__version__)"
+
+# Run a package via `uvx`
+uvx -v ruff --version
+