diff --git a/Cargo.lock b/Cargo.lock
index f8daa380b..7da47902c 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -5558,6 +5558,7 @@ version = "0.0.1"
 dependencies = [
  "fs-err 3.0.0",
  "pathdiff",
+ "self-replace",
  "serde",
  "thiserror 2.0.9",
  "toml",
@@ -5624,6 +5625,7 @@ dependencies = [
  "fs-err 3.0.0",
  "itertools 0.13.0",
  "pathdiff",
+ "self-replace",
  "thiserror 2.0.9",
  "tracing",
  "uv-fs",
diff --git a/crates/uv-tool/Cargo.toml b/crates/uv-tool/Cargo.toml
index b82791800..081162c01 100644
--- a/crates/uv-tool/Cargo.toml
+++ b/crates/uv-tool/Cargo.toml
@@ -29,6 +29,7 @@ uv-settings = { workspace = true }
 uv-state = { workspace = true }
 uv-static = { workspace = true }
 uv-virtualenv = { workspace = true }
+
 fs-err = { workspace = true }
 pathdiff = { workspace = true }
 serde = { workspace = true }
@@ -36,3 +37,6 @@ thiserror = { workspace = true }
 toml = { workspace = true }
 toml_edit = { workspace = true }
 tracing = { workspace = true }
+
+[target.'cfg(target_os = "windows")'.dependencies]
+self-replace = { workspace = true }
diff --git a/crates/uv-tool/src/lib.rs b/crates/uv-tool/src/lib.rs
index 081be9a72..773506b3d 100644
--- a/crates/uv-tool/src/lib.rs
+++ b/crates/uv-tool/src/lib.rs
@@ -184,8 +184,16 @@ impl InstalledTools {
             environment_path.user_display()
         );
 
-        // TODO(charlie): On Windows, if the current executable is in the directory,
-        // we need to use `safe_delete`.
+        // On Windows, if the current executable is in the directory, guard against self-deletion.
+        #[cfg(windows)]
+        if let Ok(itself) = std::env::current_exe() {
+            let target = std::path::absolute(&environment_path)?;
+            if itself.starts_with(&target) {
+                debug!("Detected self-delete of executable: {}", itself.display());
+                self_replace::self_delete_outside_path(&environment_path)?;
+            }
+        }
+
         fs_err::remove_dir_all(environment_path)?;
 
         Ok(())
diff --git a/crates/uv-virtualenv/Cargo.toml b/crates/uv-virtualenv/Cargo.toml
index cf51a1c59..4ab958f2a 100644
--- a/crates/uv-virtualenv/Cargo.toml
+++ b/crates/uv-virtualenv/Cargo.toml
@@ -32,3 +32,6 @@ itertools = { workspace = true }
 pathdiff = { workspace = true }
 thiserror = { workspace = true }
 tracing = { workspace = true }
+
+[target.'cfg(target_os = "windows")'.dependencies]
+self-replace = { workspace = true }
diff --git a/crates/uv-virtualenv/src/virtualenv.rs b/crates/uv-virtualenv/src/virtualenv.rs
index 89552f477..74b7fb0c5 100644
--- a/crates/uv-virtualenv/src/virtualenv.rs
+++ b/crates/uv-virtualenv/src/virtualenv.rs
@@ -105,9 +105,19 @@ pub(crate) fn create(
                 if allow_existing {
                     debug!("Allowing existing directory");
                 } else if location.join("pyvenv.cfg").is_file() {
-                    // TODO(charlie): On Windows, if the current executable is in the directory,
-                    // we need to use `safe_delete`.
                     debug!("Removing existing directory");
+
+                    // On Windows, if the current executable is in the directory, guard against
+                    // self-deletion.
+                    #[cfg(windows)]
+                    if let Ok(itself) = std::env::current_exe() {
+                        let target = std::path::absolute(location)?;
+                        if itself.starts_with(&target) {
+                            debug!("Detected self-delete of executable: {}", itself.display());
+                            self_replace::self_delete_outside_path(location)?;
+                        }
+                    }
+
                     fs::remove_dir_all(location)?;
                     fs::create_dir_all(location)?;
                 } else if location