diff --git a/Cargo.lock b/Cargo.lock
index c8a59fbb4..ab2f6dc5f 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1646,6 +1646,16 @@ dependencies = [
  "pkg-config",
 ]
 
+[[package]]
+name = "libmimalloc-sys"
+version = "0.1.35"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3979b5c37ece694f1f5e51e7ecc871fdb0f517ed04ee45f88d15d6d553cb9664"
+dependencies = [
+ "cc",
+ "libc",
+]
+
 [[package]]
 name = "libredox"
 version = "0.0.1"
@@ -1805,6 +1815,15 @@ dependencies = [
  "syn 2.0.39",
 ]
 
+[[package]]
+name = "mimalloc"
+version = "0.1.39"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "fa01922b5ea280a911e323e4d2fd24b7fe5cc4042e0d2cda3c40775cdc4bdc9c"
+dependencies = [
+ "libmimalloc-sys",
+]
+
 [[package]]
 name = "mime"
 version = "0.3.17"
@@ -2332,6 +2351,7 @@ dependencies = [
  "install-wheel-rs",
  "itertools 0.11.0",
  "miette",
+ "mimalloc",
  "pep440_rs 0.3.12",
  "pep508_rs",
  "platform-host",
@@ -2351,6 +2371,7 @@ dependencies = [
  "requirements-txt",
  "tempfile",
  "thiserror",
+ "tikv-jemallocator",
  "tokio",
  "toml 0.8.8",
  "tracing",
@@ -2403,6 +2424,7 @@ dependencies = [
  "gourgeist",
  "indicatif",
  "itertools 0.11.0",
+ "mimalloc",
  "pep508_rs",
  "platform-host",
  "platform-tags",
@@ -2413,6 +2435,7 @@ dependencies = [
  "puffin-traits",
  "pypi-types",
  "tempfile",
+ "tikv-jemallocator",
  "tokio",
  "tracing",
  "tracing-indicatif",
@@ -3535,6 +3558,26 @@ dependencies = [
  "once_cell",
 ]
 
+[[package]]
+name = "tikv-jemalloc-sys"
+version = "0.5.4+5.3.0-patched"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9402443cb8fd499b6f327e40565234ff34dbda27460c5b47db0db77443dd85d1"
+dependencies = [
+ "cc",
+ "libc",
+]
+
+[[package]]
+name = "tikv-jemallocator"
+version = "0.5.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "965fe0c26be5c56c94e38ba547249074803efd52adfb66de62107d95aab3eaca"
+dependencies = [
+ "libc",
+ "tikv-jemalloc-sys",
+]
+
 [[package]]
 name = "time"
 version = "0.3.30"
diff --git a/crates/puffin-cli/Cargo.toml b/crates/puffin-cli/Cargo.toml
index a4e7ab46d..29795f32d 100644
--- a/crates/puffin-cli/Cargo.toml
+++ b/crates/puffin-cli/Cargo.toml
@@ -54,6 +54,12 @@ tracing-tree = { workspace = true }
 url = { workspace = true }
 which = { workspace = true }
 
+[target.'cfg(target_os = "windows")'.dependencies]
+mimalloc = "0.1.39"
+
+[target.'cfg(all(not(target_os = "windows"), not(target_os = "openbsd"), any(target_arch = "x86_64", target_arch = "aarch64", target_arch = "powerpc64")))'.dependencies]
+tikv-jemallocator = "0.5.0"
+
 [dev-dependencies]
 assert_cmd = { version = "2.0.12" }
 assert_fs = { version = "1.0.13" }
diff --git a/crates/puffin-cli/src/main.rs b/crates/puffin-cli/src/main.rs
index b2833bb85..6261c209e 100644
--- a/crates/puffin-cli/src/main.rs
+++ b/crates/puffin-cli/src/main.rs
@@ -18,6 +18,22 @@ use crate::index_urls::IndexUrls;
 use crate::python_version::PythonVersion;
 use crate::requirements::RequirementsSource;
 
+#[cfg(target_os = "windows")]
+#[global_allocator]
+static GLOBAL: mimalloc::MiMalloc = mimalloc::MiMalloc;
+
+#[cfg(all(
+    not(target_os = "windows"),
+    not(target_os = "openbsd"),
+    any(
+        target_arch = "x86_64",
+        target_arch = "aarch64",
+        target_arch = "powerpc64"
+    )
+))]
+#[global_allocator]
+static GLOBAL: tikv_jemallocator::Jemalloc = tikv_jemallocator::Jemalloc;
+
 mod commands;
 mod index_urls;
 mod logging;
diff --git a/crates/puffin-dev/Cargo.toml b/crates/puffin-dev/Cargo.toml
index bbb4261e5..0c99d4f67 100644
--- a/crates/puffin-dev/Cargo.toml
+++ b/crates/puffin-dev/Cargo.toml
@@ -38,3 +38,9 @@ tracing-indicatif = { workspace = true }
 tracing-subscriber = { workspace = true }
 which = { workspace = true }
 url = { workspace = true }
+
+[target.'cfg(target_os = "windows")'.dependencies]
+mimalloc = "0.1.39"
+
+[target.'cfg(all(not(target_os = "windows"), not(target_os = "openbsd"), any(target_arch = "x86_64", target_arch = "aarch64", target_arch = "powerpc64")))'.dependencies]
+tikv-jemallocator = "0.5.0"
diff --git a/crates/puffin-dev/src/main.rs b/crates/puffin-dev/src/main.rs
index dafe745e8..a701a86c7 100644
--- a/crates/puffin-dev/src/main.rs
+++ b/crates/puffin-dev/src/main.rs
@@ -18,6 +18,22 @@ use crate::build::{build, BuildArgs};
 use crate::resolve_cli::ResolveCliArgs;
 use crate::wheel_metadata::WheelMetadataArgs;
 
+#[cfg(target_os = "windows")]
+#[global_allocator]
+static GLOBAL: mimalloc::MiMalloc = mimalloc::MiMalloc;
+
+#[cfg(all(
+    not(target_os = "windows"),
+    not(target_os = "openbsd"),
+    any(
+        target_arch = "x86_64",
+        target_arch = "aarch64",
+        target_arch = "powerpc64"
+    )
+))]
+#[global_allocator]
+static GLOBAL: tikv_jemallocator::Jemalloc = tikv_jemallocator::Jemalloc;
+
 mod build;
 mod resolve_cli;
 mod resolve_many;