diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index b0d8e18a3..ba7a4b4d1 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -223,6 +223,9 @@ jobs:
           tool: cargo-nextest
 
       - name: "Cargo test"
+        env:
+          # Retry more than default to reduce flakes in CI
+          UV_HTTP_RETRIES: 5
         run: |
           cargo nextest run \
             --features python-patch \
@@ -256,6 +259,9 @@ jobs:
           tool: cargo-nextest
 
       - name: "Cargo test"
+        env:
+          # Retry more than default to reduce flakes in CI
+          UV_HTTP_RETRIES: 5
         run: |
           cargo nextest run \
             --no-default-features \
@@ -300,6 +306,8 @@ jobs:
       - name: "Cargo test"
         working-directory: ${{ env.UV_WORKSPACE }}
         env:
+          # Retry more than default to reduce flakes in CI
+          UV_HTTP_RETRIES: 5
           # Avoid permission errors during concurrent tests
           # See https://github.com/astral-sh/uv/issues/6940
           UV_LINK_MODE: copy
diff --git a/crates/uv/tests/it/edit.rs b/crates/uv/tests/it/edit.rs
index 18170cff9..ddaed434f 100644
--- a/crates/uv/tests/it/edit.rs
+++ b/crates/uv/tests/it/edit.rs
@@ -11877,7 +11877,9 @@ async fn add_unexpected_error_code() -> Result<()> {
         "#
     })?;
 
-    uv_snapshot!(context.filters(), context.add().arg("anyio").arg("--index").arg(server.uri()), @r"
+    uv_snapshot!(context.filters(), context.add().arg("anyio").arg("--index").arg(server.uri())
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 2
     ----- stdout -----
diff --git a/crates/uv/tests/it/network.rs b/crates/uv/tests/it/network.rs
index 1a5805970..a9376e07e 100644
--- a/crates/uv/tests/it/network.rs
+++ b/crates/uv/tests/it/network.rs
@@ -3,6 +3,7 @@ use std::{env, io};
 use assert_fs::fixture::{ChildPath, FileWriteStr, PathChild};
 use http::StatusCode;
 use serde_json::json;
+use uv_static::EnvVars;
 use wiremock::matchers::method;
 use wiremock::{Mock, MockServer, ResponseTemplate};
 
@@ -48,7 +49,9 @@ async fn simple_http_500() {
         .pip_install()
         .arg("tqdm")
         .arg("--index-url")
-        .arg(&mock_server_uri), @r"
+        .arg(&mock_server_uri)
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 2
     ----- stdout -----
@@ -72,7 +75,9 @@ async fn simple_io_err() {
         .pip_install()
         .arg("tqdm")
         .arg("--index-url")
-        .arg(&mock_server_uri), @r"
+        .arg(&mock_server_uri)
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 2
     ----- stdout -----
@@ -99,7 +104,9 @@ async fn find_links_http_500() {
         .arg("tqdm")
         .arg("--no-index")
         .arg("--find-links")
-        .arg(&mock_server_uri), @r"
+        .arg(&mock_server_uri)
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 2
     ----- stdout -----
@@ -125,7 +132,9 @@ async fn find_links_io_error() {
         .arg("tqdm")
         .arg("--no-index")
         .arg("--find-links")
-        .arg(&mock_server_uri), @r"
+        .arg(&mock_server_uri)
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 2
     ----- stdout -----
@@ -154,7 +163,9 @@ async fn direct_url_http_500() {
     let filters = vec![(mock_server_uri.as_str(), "[SERVER]")];
     uv_snapshot!(filters, context
         .pip_install()
-        .arg(format!("tqdm @ {tqdm_url}")), @r"
+        .arg(format!("tqdm @ {tqdm_url}"))
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 1
     ----- stdout -----
@@ -180,7 +191,9 @@ async fn direct_url_io_error() {
     let filters = vec![(mock_server_uri.as_str(), "[SERVER]")];
     uv_snapshot!(filters, context
         .pip_install()
-        .arg(format!("tqdm @ {tqdm_url}")), @r"
+        .arg(format!("tqdm @ {tqdm_url}"))
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 1
     ----- stdout -----
@@ -239,7 +252,9 @@ async fn python_install_http_500() {
         .python_install()
         .arg("cpython-3.10.0-darwin-aarch64-none")
         .arg("--python-downloads-json-url")
-        .arg(python_downloads_json.path()), @r"
+        .arg(python_downloads_json.path())
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 1
     ----- stdout -----
@@ -269,7 +284,9 @@ async fn python_install_io_error() {
         .python_install()
         .arg("cpython-3.10.0-darwin-aarch64-none")
         .arg("--python-downloads-json-url")
-        .arg(python_downloads_json.path()), @r"
+        .arg(python_downloads_json.path())
+        .env_remove(EnvVars::UV_HTTP_RETRIES)
+        .env(EnvVars::UV_TEST_NO_HTTP_RETRY_DELAY, "true"), @r"
     success: false
     exit_code: 1
     ----- stdout -----