diff --git a/crates/uv-interpreter/src/get_interpreter_info.py b/crates/uv-interpreter/src/get_interpreter_info.py
index 4d4b4f2b4..0b1d6fe96 100644
--- a/crates/uv-interpreter/src/get_interpreter_info.py
+++ b/crates/uv-interpreter/src/get_interpreter_info.py
@@ -169,6 +169,19 @@ def get_virtualenv():
             "data": expand_path(sysconfig_paths["data"]),
         }
     else:
+        # Disable the use of the setuptools shim, if it's injected. Per pip:
+        #
+        # > If pip's going to use distutils, it should not be using the copy that setuptools
+        # > might have injected into the environment. This is done by removing the injected
+        # > shim, if it's injected.
+        #
+        # > See https://github.com/pypa/pip/issues/8761 for the original discussion and
+        # > rationale for why this is done within pip.
+        try:
+            __import__("_distutils_hack").remove_shim()
+        except (ImportError, AttributeError):
+            pass
+
         # Use distutils primarily because that's what pip does.
         # https://github.com/pypa/pip/blob/ae5fff36b0aad6e5e0037884927eaa29163c0611/src/pip/_internal/locations/__init__.py#L249
         import warnings
@@ -317,6 +330,19 @@ def get_scheme():
         Based on (with default arguments):
             https://github.com/pypa/pip/blob/ae5fff36b0aad6e5e0037884927eaa29163c0611/src/pip/_internal/locations/_distutils.py#L115
         """
+        # Disable the use of the setuptools shim, if it's injected. Per pip:
+        #
+        # > If pip's going to use distutils, it should not be using the copy that setuptools
+        # > might have injected into the environment. This is done by removing the injected
+        # > shim, if it's injected.
+        #
+        # > See https://github.com/pypa/pip/issues/8761 for the original discussion and
+        # > rationale for why this is done within pip.
+        try:
+            __import__("_distutils_hack").remove_shim()
+        except (ImportError, AttributeError):
+            pass
+
         import warnings
 
         with warnings.catch_warnings():  # disable warning for PEP-632